Fish oil supplementation improves histological changes after sciatic nerve injury in rats

Peripheral nerve injury often leads to neuropathic pain. The potential effect of dietary supplementation with fish oil [Omega-3] fatty acids on the injured sciatic nerve was studied in albino rats. 25 adult male albino rats weighing 200g were divided into three groups. Group I consisted of five rats were fed a non purified diet supplemented with olive oil for six weeks, they were used as control group. Group II consisted of ten rats were undergone sciatic nerve crush injury and fed a non purified diet supplemented with olive oil for six weeks, they were used as the injured comparative group. Group III consisted of ten rats were undergone sciatic nerve crush injury and were fed a non purified diet supplemented with [Omega-3] fatty acid enriched fish oil concentrate at a dose of 0.5 g/kg/day for six weeks. Histological study showed partially intact neurolemmal sheath, absence of endoneural oedema and signs of regeneration in group three in contrast with group two in which there were apparent signs of degeneration. This beneficial effect of fish oil on injured sciatic nerve with attenuated histological damage suggested a treatment role for patients suffering from neuropathic pain

Safety and efficacy of Esmolol as add on therapy in acute unstable angina

The present study examined the hemodynamic and anti-ischemic effects of esmolol in 20 patients with unstable angina. Two patients required a termination of infusion at the titration period because of hypotension, but they recovered hemodynamic stability within 30 minutes of termination of the infusion. During esmolol infusion, two patients of those receiving intravenous nitroglycerin required a downward adjustment of nitroglycerin infusion rate to maintain systolic blood pressure >90 mm hg. These results suggested that esmolol safely and effectively lowered both arterial pressure and heart rate in patients with acute ischemia